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[ Source: t-coffee  ]

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Multiple Sequence Alignment

T-Coffee is a multiple sequence alignment package. Given a set of sequences (Proteins or DNA), T-Coffee generates a multiple sequence alignment. Version 2.00 and higher can mix sequences and structures.

T-Coffee allows the combination of a collection of multiple/pairwise, global or local alignments into a single model. It can also estimate the level of consistency of each position within the new alignment with the rest of the alignments. See the pre-print for more information

T-Coffee has a special called M-Coffee that makes it possible to combine the output of many multiple sequence alignment packages. In its published version, it uses MUSCLE, PROBCONS, POA, DiAlign-TS, MAFFT, Clustal W, PCMA and T-Coffee. A special version has been made for Debian, DM-Coffee, that uses only free software by replacing Clustal W by Kalign. Using the 8 Methods of M-Coffee can sometimes be a bit heavy. You can use a subset of your favorite methods if you prefer.

Tags: Field: Biology, Bioinformatics, Implemented in: implemented-in::c, interface::commandline, Role: Program, Scope: Utility, Purpose: use::analysing, use::comparing, Supports Format: Need an extra tag, works-with-format::plaintext, works-with::TODO

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Download t-coffee

Download for all available architectures
Architecture Version Package Size Installed Size Files
alpha (unofficial port) 997.0 kB3,340.0 kB [list of files]
amd64 1,007.5 kB2,715.0 kB [list of files]
arm64 894.1 kB2,634.0 kB [list of files]
armel 846.5 kB2,569.0 kB [list of files]
armhf 857.3 kB1,929.0 kB [list of files]
hppa (unofficial port) 910.9 kB2,720.0 kB [list of files]
i386 1,010.5 kB3,033.0 kB [list of files]
ia64 (unofficial port) 1,208.2 kB5,405.0 kB [list of files]
m68k (unofficial port) 893.9 kB2,825.0 kB [list of files]
mips64el 950.6 kB3,380.0 kB [list of files]
ppc64 (unofficial port) 1,020.1 kB3,466.0 kB [list of files]
ppc64el 1,063.4 kB3,402.0 kB [list of files]
riscv64 996.7 kB2,295.0 kB [list of files]
s390x 921.2 kB2,974.0 kB [list of files]
sh4 (unofficial port) 1,073.0 kB2,570.0 kB [list of files]
sparc64 (unofficial port) 835.5 kB3,150.0 kB [list of files]
x32 (unofficial port) 1,010.6 kB2,710.0 kB [list of files]