Testing Haplotype Effects In Association Studies
The objectif of the THESIAS program is to performed haplotype-based
association analysis in unrelated individuals. This program is based
on the maximum likelihood model described in Tregouet et al. 2002
(Hum Mol Genet 2002,11: 2015-2023) and is linked to the SEM algorithm
(Tregouet et al. Ann Hum Genet 2004,68: 165-177).
THESIAS allows one to simultaneous estimate haplotype frequencies
and their associate effects on the phenotype of interest.
In this new THESIAS release, quantitative, qualitative (logistic
and matched-pair analysis), categorical and survival outcomes can be
studied. X-linked haplotype analysis is also feasible.
Covariate-adjusted haplotype effects as well as haplotype x covariate
interactions can also be investigated.
