Package: dialign-tx (1.0.2-1)

Segment-based multiple sequence alignment

DIALIGN-TX is a command line tool to perform multiple alignment of protein or DNA sequences. It is a complete reimplementation of the segment-base approach including several new improvements and heuristics that significantly enhance the quality of the output alignments compared to DIALIGN 2.2 and DIALIGN-T. For pairwise alignment, DIALIGN-TX uses a fragment-chaining algorithm that favours chains of low-scoring local alignments over isolated high-scoring fragments. For multiple alignment, DIALIGN-TX uses an improved greedy procedure that is less sensitive to spurious local sequence similarities.

DIALIGN-TX has been published in Amarendran R. Subramanian, Michael Kaufmann, Burkhard Morgenstern: Improvement of the segment-based approach for multiple sequence alignment by combining greedy and progressive alignment strategies, Algorithms for Molecular Biology 3:6, 2008

Tags: Field: Biology, Bioinformatics, Implemented in: C, Role: Program, Scope: Utility, Purpose: Comparing, Supports Format: Plain Text